Induction of telithromycin resistance in Streptococcus pneumoniae
نویسندگان
چکیده
منابع مشابه
Induction of telithromycin resistance in Streptococcus pneumoniae.
efficacy; whereas in the patients treated with penicillin V, no differences would be found with respect to bacteriological (P = 1.0) and clinical efficacy (P = 1.0) between patients with a clarithromycin-susceptible strain and those with a clarithromycin-resistant strain. In the PP analysis of the group treated with clarithromycin, clinical cure at visit three was obtained in 95.2% (120 of 126)...
متن کاملTelithromycin-resistant Streptococcus pneumoniae
To the Editor: In recent years, antimicrobial drug resistance in Streptococcus pneumoniae has increased worldwide and is a major health concern. Resistance to β-lac-tams and macrolides, considered to be first-line therapeutic agents, is particularly high in France and many Asian countries (1–3). Resistance to new fluoroquinolones is reported with increasing frequency, which emphasizes the need ...
متن کاملMechanisms of resistance to telithromycin in Streptococcus pneumoniae.
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolates of resistant Streptococcus pneumoniae have been documented. Mutations in key telithromycin-binding sites such as domains II and V of the 23S rRNA and ribosomal proteins L4 and L22, as well as mutations of the resistance determinant erm(B) are associated with elevated telithromycin MICs. Mutatio...
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The antimicrobial efflux system encoded by the operon mef(E)-mel on the mobile genetic element MEGA in Streptococcus pneumoniae and other Gram-positive bacteria is inducible by macrolide antibiotics and antimicrobial peptides. Induction may affect the clinical response to the use of macrolides. We developed mef(E) reporter constructs and a disk diffusion induction and resistance assay to determ...
متن کاملHigh-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.
A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4.
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2003
ISSN: 1460-2091
DOI: 10.1093/jac/dkg411